Prof. RNDr. Vladimír Sklenář, DrSc.

Education, Scientific and Pedagogical Carrier

Faculty of Science, Masaryk University, Brno, Chemistry, 1974.
RNDr degree: Department of Theoretical and Physical Chemistry
Faculty of Science, Masaryk University, Brno, 1975.
CSc. degree (equivalent to PhD.), Technical University, Brno, 1984.
Associate professor, Faculty of Science, Masaryk University, Brno, 1992
DrSc. degree, Institute of Chemical Technology, Prague, 1996
Full professor, Faculty of Science, Masaryk University, Brno, 1997

Employment and Scientific Sojourns

Professional Interests

NMR methods, development of multi-dimensional FT NMR techniques, spin system dynamics, theoretical description of spin system behaviour, gradient-enhanced NMR spectroscopy, multiple-resonance techniques, Ab Initio calculations of NMR parameters, NMR-based structural studies of nucleic acids and proteins.


  • Žídek, L., Wu, H., Feigon, J., Sklenář, V.: J. Biomol. NMR 2001, 21, 2, 153-160: Measurement of small scalar and resiudal dipolar couplings in purine and pyrimidine bases.
  • Trantírek, L., Štefl, R., Masse, J., Feigon, J., Sklenář, V.: J. Biomol. NMR 2002, 23, 1, 1-12: Determination of the glycosidic torsion angels in uniformly C-13 labeled nucleic acids from vicinal coupling constants 3JC2/4-H1' and 3JC6/8-H1'.
  • Fiala, R. and Sklenář, V., Ed. O. Zerbe in Series Methods and Principles in Medicinal Chemistry, Eds. Mannhold, R., Kubinyi, H., Folkers, G.: NMR od Nucleic Acids 2002, 121-145.
  • Padrta, P., Štefl, R., Králík, L., Žídek, L., Sklenář, V.: J. Biomol. NMR 2002, 24, 1, 1-14: Refinement of d(GCGAAGC) Hairpin Structure Using One- and Two-Bond Residual Dipolar Couplings.
  • Sychrovský, V., Vacek, J., Hobza, P., Žídek, L., Sklenář, V., Cremer, D.: J. Phys. Chem. B 2002, 106, 29, s. 10242-10250: Exploring the Structure of a DNA Hairpin with the Help of NMR Spin-spin Coupling Constants: An Experimental and Quantum Chemical Investigation.
  • Veselá, D., Marek R., Ubik, K., Lunerová, K., Sklenář, V., and Suchý, V.: Phytochemistry 2002, 61, 967-970: Dracophane, a Novel Metacyclophane Derivative from Resin of Dracaena Cinnabari Balf.
  • Munzarová, M., Sklenář, V.: J. Amer. Chem. Soc. 2002, 124, 10666-10667: Three-Bond Sugar-Base Coupling in Purine versus Pyrimidine Nucleosides: A DFT Study of Karplus Relationships for 3JC2/4-H1' and 3JC6/8-H1' in DNA.
  • Padrta, P. and Sklenář, V.: J. Biol. NMR 2002, 24, 4, 339-349: Program MULDER - A Tool for extracting torsion angles from NMR data.
  • Sychrovský, V., Schneider, B., Hobza, P., Žídek, L., Sklenář, V.: Phys. Chem.Chem. Phys. 2003, 5, 734-739: The Effect of Water on NMR Spin-Spin Couplings in DNA: Improvement of Calculated Values by Application of Two Solvent Models.
  • Munzarová, M., Sklenář, V.: J. Amer. Chem. Soc. 2003, 125, 3649-3658: A DFT Analysis of NMR Scalar Interactions Across the Glycosidic Bond in DNA.
  • Marek, R., Sečkářová, P., Hulová, D., Marek, J., Dostál, J., Sklenář, V.: J. Nat. Prod. 2003, 66, 4, 481-486: Palmatine and Berberine Isolation Artifacts..
  • Žídek, L., Padrta, P., Chmelík, J. Jr., and Sklenář, V.:J. Magn. Reson. 2003, 162, 385-395: Internal Consistency of NMR Data Obtained in Partially Aligned Biomacromolecules.
  • Vorlíčková, M., Kypr, J., and Sklenář, V.: Encyclopedia of Analytical Science 2nd Edition, Academic Press: Nucleic Acids: (c) spectroscopic methods.
  • Křížová, H., Žídek, L., Stone, M., Novotny, M.V., and Sklenář, V., J. Biomol. NMR 2004, 28, 4, 369-384: Temperature Dependent Backbone Dynamics of Major Urinary Protein-I Complexed with the Pheromone 2-sec-Butyl-4,5-dihydrothiazole.
  • Štefl, R., Wu, H., Ravindranathan, S., Sklenář, V., and Feigon, J.:Proc. Nat. Acad. Sci. 2004, 101, 5, 1177-1182: DNA A-tract bending in three dimensions-solving the dA4T4 versus dT4A4 conundrum.
  • Fiala, R., Munzarová, M., and Sklenář, V.:J. Biomol. NMR 2004, 29, 477-490. Experiments for Correlating Quaternary Carbons in RNA Bases.
  • Sečkářová, P., Marek, R., Maliňáková, K., Kohlemainen, E., Hocková, , D., Hocek, M., and Sklenář, V.: Tetrahedron Lett. 2004, 45, 6259-6263. Direct determination of tautomerism in purine derivatives by low-temerature NMR spectroscopy.
  • Marek, R. and Sklenář, V.: Ann. Rep. NMR Spect. 2005, 54, 201-242: NMR Studies of Purines.

National Centre for Biomolecular Research
NMR Laboratory
Faculty of Science, Masaryk University
Kotlarska 2, CZ-611 37 Brno
tel.:+420 - 549 497 022
fax :+420 - 549 492 556

last modification: Tue Mar 8 20:43:32 MET 2005